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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)
This positioning makes it vulnerable to inflammation, fraying, and tears
2020;8:2002797 Wang JC, Hill SP, Dilbeck T, Ogunsolu OO, Banerjee T, Hanson K
Cancer Discovery 2012 2
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